Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin
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چکیده
منابع مشابه
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15 صفحه اولThe presence of amorpha-4, 11-diene synthase, a key enzyme in artemisinin production in ten Artemisia species
BACKGROUND AND THE PURPOSE OF THE STUDY Artemisinin is one of the most effective medicine against malaria, which is produced naturally by Artemisia annua in low yield. It is produced in a metabolic pathway, in which several genes and gene products are involved. One of the key genes in this pathway is am1, which encodes amorpha-4, 11-diene synthase (ADS), a key enzyme in artemisinin biosynthesis...
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amorpha-4, 11-diene synthase (ads) gene is the first and important gene in artemisinin biosynthesis pathway that why for many researchers, the study of how to regulate of this gene is important. transcription factors can change the expression rate of several genes simultaneously. in this study, six wild accessions of artemisia annua, collected from golestan province, were used. many known trans...
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ژورنال
عنوان ژورنال: Planta
سال: 2001
ISSN: 0032-0935,1432-2048
DOI: 10.1007/s004250000428